HORDB

ID: hor003116
Uniprot ID: A0SIF1
Protein name: RLRF peptide 1
Gene name: sNPF
Organism: Anopheles gambiae (African malaria mosquito)
Family: NPY family
Source: animal
Expression: Expressed in all body parts of larva, pupae and adults.
Disease: NA
Comments: NA
Taxonomy: gambiae species complex, Pyretophorus, Cellia (subgenus), Anopheles (genus), Anophelinae (subfamily), Culicidae (family), Culicoidea (superfamily), Culicomorpha (infraorder), Nematocera (suborder), Diptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005184 neuropeptide hormone activity
GO BP: GO:0007218 neuropeptide signaling pathway; GO:0032095 regulation of response to food; GO:0040014 regulation of multicellular organism growth
GO CC: GO:0005576 extracellular region

Sequence: AVRSPSLRLRF
Length: 11
Propeptide: MYRINLTTFTLLLVLAVGSLMSESLHPSDGAINDLYEYLLQREYAAPVSYADHQIKRKAVRSPSLRLRFGRRSDPSVPLRPEEDELIDQKAIRAPQLRLRFGRNDPLWTSFNENALLEENFEKRAPSQRLRWGRSNLFGNLVNQFQQDDVMQQKTIRAPQLRLRFGRTDPSWAMYNEHQLTTGQQAQPANEASEKRAPTQRLRWGRSDPALAKDSSEDKALDVEESENTNADDK
Signal peptide: MYRINLTTFTLLLVLAVGSLMS
Modification: T11 Phenylalanine amide
Glycosylation: NA
Mutagenesis: NA

Function: Has a role in inhibiting host-seeking behavior during a reproductive cycle
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: sNPF receptor:3.0nM
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

AF-Q9SV72-F1.pdb

hor003116_AF2.pdb

hor003116_ESM.pdb

Mass:	148009	Formula:	C58H100N20O14
Absent amino acids:	CDEGHIKMNQTWY	Common amino acids:	R
pI:	12.8	Basic residues:	3
Polar residues:	2	Hydrophobic residues:	5
Hydrophobicity:	-2.73	Boman Index:	-3289
Half-Life:	4.4 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	106.36
Instability Index:	14150.91	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 17140700
Title: Characterization and Expression of the Short Neuropeptide F Receptor in the African Malaria Mosquito, Anopheles Gambiae